Understanding Biomarkers in the Context of Memory Health

Memory health is one of the biggest concerns people face as they age. Yet too often, people wait until severe symptoms appear to seek help. Biomarkers are changing this story.

These measurable signals inside the body can reveal brain changes years before memory loss begins. At Neurogen, we’re making these tools not only accessible but also meaningful to help you take action earlier with clarity and confidence.

What Are Biomarkers? Everyday Clues from the Body

Biomarkers are measurable signs in the body that help explain how healthy you are. These common biomarkers are used every day by doctors in lab tests:

• Hemoglobin A1c serves as a long-term snapshot of blood sugar levels and is often used to adjust diabetes care.
• Vitamin D levels reveal whether your bones and immune system are getting the support they need.
• White blood cell counts alert doctors when your immune system is fighting an infection.

In the same way, memory health biomarkers tell the story of what’s happening in the brain. Proteins such as p-tau217, amyloid, and GFAP start to shift long before symptoms like forgetfulness or confusion become significant.

By measuring these signals, you can understand internal shifts in your body that may indicate potential future memory health issues, allowing you to take informed, proactive steps for your brain health.

Different Types of Memory Health Biomarkers

Memory biomarkers come in a few different forms, each giving a slightly different perspective:

• Blood-based biomarkers: Simple blood draws that detect proteins such as p-tau217 and amyloid ratios. These are gaining traction for their accuracy and ease of access.
• CSF biomarkers: Cerebrospinal fluid markers measured through spinal taps were once considered the gold standard, but are far more invasive for patients.
• Imaging biomarkers: PET scans and MRIs, which visualize brain structure and function, are often expensive and less practical for routine use.
• Digital and lifestyle markers: Cognitive assessments, questionnaires, and lifestyle surveys that help track performance and risks over time.

Each method has trade-offs, but blood-based biomarkers are especially exciting because they combine clinical accuracy with everyday accessibility.

Recent Innovations in Memory Health Biomarker Research

In just the past few years, biomarker science has advanced at an unprecedented pace.

Once limited to invasive spinal taps and costly scans, we now have blood-based tests that are reshaping how clinicians think about early detection. For example:

• NIH-funded studies have demonstrated that blood biomarkers can predict brain atrophy and long-term cognitive decline, sometimes years before significant symptoms appear.
• Clinical guidelines are beginning to formally recognize blood-based biomarkers, signaling a shift toward broader adoption in memory clinics.
• Research teams worldwide are testing new proteins and refining methods to make results more consistent and widely accessible.

This momentum signals a clear shift from reactive care to proactive care built on early warning signals.

How We Integrate Biomarker Data into the Neurogen Ecosystem

Biomarker testing alone offers valuable signals, but signals only matter when you know what to do with them. That’s why Neurogen has built a complete care pathway

• Validated assays: We follow the most advanced testing standards to ensure accurate measurement of p-tau217, one of the most reliable Alzheimer’s-related biomarkers.
• At-home accessibility: Remote blood collection makes accurate testing part of everyday life.
• Virtual care ecosystem: In pilot studies, our approach reduced the time to intervention by detecting changes before significant memory decline.
• Neurologist guidance: Specialists interpret results and provide clear, personalized next steps.
• Holistic integration: We combine biomarker data with digital cognitive assessments and lifestyle surveys to create a comprehensive view of memory health.

With Neurogen, biomarkers don’t stop at lab results. They become a foundation for proactive, personalized care that empowers individuals to act with confidence and take control of their health.

How Early Detection Helps You Take Charge of Your Memory Health

When it comes to memory health, accuracy is essential. Biomarkers must closely reflect brain changes and reliably predict progression.

Pairing accuracy with detection helps people gain powerful advantages to take control of their memory health and opens the door for:

• Lifestyle adjustments in sleep, exercise, and nutrition may slow decline.
• At-home accessibility: Remote blood collection makes accurate testing part of everyday life.
• Earlier medical monitoring that leads to timely interventions.
• Peace of mind in replacing uncertainty with clarity.

The earlier you know, the more options you have. With at-home testing and neurologist-backed insights, Neurogen helps transform uncertainty into informed, actionable steps.

Take Charge of Your Memory Health With Neurogen

Biomarkers are transforming the way we approach memory health, making early detection both accurate and accessible.

By combining validated science with practical tools and human support, we empower individuals to take control of their memory health today — not years from now.