THE SCIENCE

The P-tau217 Blood Test: Redefining Early Alzheimer’s Detection

At Neurogen, we test for brain-derived p-tau217 — one of the most specific and scientifically advanced biomarkers in Alzheimer’s research — to identify early signs of memory decline long before severe symptoms appear.
Older women resting her head on older mans shoulder
Elderly women looking out the window
Baby hand resting on senior citizen hand
Older african american man with beanie on looking straight ahead
Older women resting her head on older mans shoulder
Elderly women looking out the window
Baby hand resting on senior citizen hand
Older african american man with beanie on looking straight ahead

The Basics of Brain Health

Your brain’s health is shaped by a delicate balance of genetics, lifestyle, and age. Memory, focus, and decision-making all depend on how well your brain’s cells communicate and stay protected over time. When changes occur — whether from stress, aging, or disease — early detection becomes essential. That’s why understanding your cognitive function through reliable testing is the first step toward protecting it.

Two men hugging each other

OF OLDER AMERICANS

living with mild cognitive impairment receive a diagnosis.

Alzheimer’s vs. Dementia

Dementia is a broad term describing a decline in cognitive function severe enough to interfere with daily life. Alzheimer’s disease is the most common cause of dementia, responsible for up to 80% of cases. It begins silently, with subtle changes in the brain that may start years before memory symptoms appear. Identifying these changes early through biomarkers like p-tau217 opens the door to earlier intervention and better outcomes.

Symptoms of Alzheimer’s Disease


Progression


Causes of Alzheimer’s Disease

Early Detection Right at Home

Neurogen makes early Alzheimer’s detection accessible and precise. By combining a brief online cognitive assessment with an at-home p-tau217 blood test, we help individuals and families gain valuable insights into brain health, years before severe symptoms may appear. This seamless approach brings clinical-grade testing into the comfort of your home, turning proactive care into an empowering, everyday choice.

Revolutionary Testing Technology

P-tau217 is a key blood biomarker linked to Alzheimer’s disease that begins to change long before memory symptoms surface. Measuring p-tau217 through a simple blood test allows for earlier detection and ongoing monitoring of potential cognitive changes. Neurogen’s testing technology delivers clinical-quality accuracy from a small, at-home blood sample, offering insights comparable to advanced imaging methods like PET scans, but with greater convenience and at a fraction of the cost. It’s a breakthrough that brings the future of Alzheimer’s detection directly to you.

Our testing method is highly accurate, providing clinical quality results from an at-home blood sample.

This blood test performs as well as the current standard of care (PET-scans) at a fraction of the cost.

Woman performing a medical test on her arm

Early detection gives
you time to act

When Alzheimer's is detected early, you have more time to take proactive steps to better protect and care for your cognitive health.

Lifestyle
Changes

Slowing Disease
Progression

New Detection
Methods

Treatment
Options

Develop a
Care Plan

Maintain
Independence

Lifestyle Changes

You can reduce your risk of cognitive decline by up to 60% by making healthy changes in your lifestyle. Some key lifestyle factors are smoking, drinking, physical activity, sleep, and diet.

One-of-a-Kind Testing and Exceptional Care

At Neurogen, we do more than deliver results — we partner with you to take control of brain health with confidence. Our innovative approach combines advanced p-tau217 testing with a comprehensive care ecosystem designed to support you from discovery to action.

Each step connects you with leading, board-certified neurologists and Alzheimer’s disease specialists who interpret your results, explain what they mean, and guide your next steps. From early detection through ongoing care, Neurogen provides clinical precision and compassionate support — ensuring you’re never alone on the path to protecting your memory health.

Woman opening her Alzheimer’s test kit

Led by scientists

Our leaders are experts in neurology, dementia care and life sciences innovation. Their mission is to ensure that more patients have access to the highest quality care.

Dr. Rany Aburashed, CEO & Founder, Neurogen Biomarking

Dr. Rany Aburashed

CEO & Founder

  • check icon Over 15 years expertise in neurology and neuroimmunology, coupled with a proven track record of leadership in clinical care and healthcare systems.
  • check icon Combines dedication to patient care as Chief Medical Officer of Insight Corporation with a commitment to advancing innovative diagnostic solutions for neurodegenerative diseases.
  • check icon Has led numerous clinical trials, contributing to breakthroughs in the treatment of multiple sclerosis and related conditions.
  • check icon Combines big-picture ambition with a focus on sustainable and effective solutions that improve lives and redefine the standards of patient care.
Elisabeth Thijssen, PhD, Chief Scientific Officer, Neurogen Biomarking

Elisabeth Thijssen, PhD

Chief Scientific Officer

  • check icon Leads Neurogen’s scientific vision, leveraging over a decade of expertise in neurodegenerative research and biomarker innovation.
  • check icon Her groundbreaking work on Alzheimer’s blood tests, featured in Nature Medicine and The Lancet Neurology, has redefined early detection of the disease.
  • check icon Has led high-impact R&D and business initiatives across consulting and biotech, forging innovative solutions and strategic partnerships that drive meaningful impact.
  • check icon Holds a Cum Laude PhD in Neurochemistry of Alzheimer's Disease, a Master's in Pharmaceutical Sciences, and a Bachelor's in Biomedical Sciences.
Kenneth Bahk, PhD, Chief Strategy Officer, Neurogen Biomarking

Kenneth Bahk, PhD

Chief Strategy Officer

  • check icon Shapes Neurogen’s strategic vision, bringing decades of experience in healthcare innovation, investment, and ecosystem building.
  • check icon Accomplishments include founding, building, and investing in transformative diagnostic and life science startups, achieving multiple market-leading exits.
  • check icon Has driven impactful R&D, policy, and business initiatives with organizations including the White House, JP Morgan, the Mayo Clinic, as well as leading professional groups in laboratory medicine and innovation.
  • check icon Holds an MS in Neurobiology, a PhD in Biochemistry and Molecular Biology, and an MBA from Northwestern University.

"The current landscape of Alzheimer's diagnosis remains reactionary and often a diagnosis is made quite late. This puts us at a massive disadvantage in addressing our modifiable risk factors, gaining access to disease-modifying therapies in time, and guidance towards cutting-edge clinical trials when patients remain clinically eligible. Our goal at Neurogen Biomarking is to close this gap and help guide patients into the broader ecosystem in the most clinically and scientifically accurate way at a significantly earlier time."

- Dr. Rany Aburashed

References

1 What is Alzheimer's Disease? Alzheimer's Association. https://www.alz.org/alzheimers-dementia/what-is-alzheimers

2 Mild Cognitive Impairment (MCI) Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/mild-cognitive-impairment/symptoms-causes/syc-20354578

3 Alzheimer's Disease, Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/alzheimers-disease/symptoms-causes/syc-20350447

4 Stages of Alzheimer's. Alzheimer's Association. https://www.alz.org/alzheimers-dementia/stages

5 Dhana K, et al. Healthy lifestyle and the risk of Alzheimer's dementia: Findings from two longitudinal studies. Neurology. 2020; 95:1-10. doi: 10>1212/WNL. 0000000000009816

6 Preventing Alzheimer's Disease: What Do We Know? National Institute on Aging. https://www.nia.nih.gov/health/alzheimers-and-dementia/preventing-alzheimers-disease-what-do-we-know

7 Mielke (2024) Recommendations for clinical implementation of blood-based biomarkers for Alzheimer's disease.

8 McDade (2022) - Clinical Trial Alzheimers Res Ther. 2022 Dec 21;14(1):191. doi: 10.1186/s13195-022-01124-2. Lecanemab in patients with early Alzheimer's disease: detailed results on biomarker, cognitive, and clinical effects from the randomized and open-label extension of the phase 2 proof-of-concept study.

9 Pontecorvo (2022) - JAMA Neurol. 2022;79(12):1250-1259. doi:10.1001/jamaneurol.2022.3392

10 Cummings (2024) - Alzheimer's disease drug development pipeline: 2024